On the specificity of the inhibitory effect of trilostane and aminoglutethimide on adrenocortical steroidogenesis in guinea pig

F. Lambert; F. Corcelle-Cerf; J. Lammerant; J. Kolanowski

DOI:10.1016/0303-7207(84)90134-5

Corpus ID: 45766843

On the specificity of the inhibitory effect of trilostane and aminoglutethimide on adrenocortical steroidogenesis in guinea pig

@article{Lambert1984OnTS,
  title={On the specificity of the inhibitory effect of trilostane and aminoglutethimide on adrenocortical steroidogenesis in guinea pig},
  author={F. Lambert and F. Corcelle-Cerf and J. Lammerant and J. Kolanowski},
  journal={Molecular and Cellular Endocrinology},
  year={1984},
  volume={37},
  pages={115-120}
}

F. Lambert, F. Corcelle-Cerf, +1 author J. Kolanowski

Published 1984

Biology, Medicine

Molecular and Cellular Endocrinology

The effect of trilostane and aminoglutethimide on steroidogenesis was studied on isolated guinea pig adrenocortical cells in order to verify whether, in addition to the inhibitory influence of trilostane on 3beta-hydroxysteroid dehydrogenase and isomerase and the inhibition by aminoglutethimide of pregnenolone formation, these inhibitors may also affect other enzymatic steps of cortisol synthesis. While trilostane completely abolished cortisol production in response to ACTH with concomitant… CONTINUE READING

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