On the safety of Aspergillus niger – a review

  title={On the safety of Aspergillus niger – a review},
  author={Erwin Dr Schuster and Nigel Stuart Dunn-Coleman and Jens Christian Frisvad and Patrick van Dijck},
  journal={Applied Microbiology and Biotechnology},
Abstract.Aspergillus niger is one of the most important microorganisms used in biotechnology. It has been in use already for many decades to produce extracellular (food) enzymes and citric acid. In fact, citric acid and many A. niger enzymes are considered GRAS by the United States Food and Drug Administration. In addition, A. niger is used for biotransformations and waste treatment. In the last two decades, A. niger has been developed as an important transformation host to over-express food… 

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Investigation into the source of the antigen showed that whereas, in some areas of the plant, A niger spores were present, in others there were no detectable spores, in these areas extracts of filters from air samplers were shown by RAST inhibition to contain A nigers antigens, indicating that the culture fluid was generating airborne antigen.

Naphtho-gamma-pyrone production by Aspergillus niger isolated from stored cottonseed

Aspergillus niger was found to be the predominant fungal contaminant of stored cottonseed and the major components in the mixture were eight different naphtho-gamma-pyrones, which may be a precursor in the biosynthesis of the hydrated aurasperones.

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