On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes.

@article{Zaid1999OnTR,
  title={On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes.},
  author={Ahmed A. Zaid and Rong Tao Li and Katar{\'i}na Luciakov{\'a} and Peter Bar{\'a}th and Susana Nery and B. Dean Nelson},
  journal={Journal of bioenergetics and biomembranes},
  year={1999},
  volume={31 2},
  pages={129-35}
}
To gain insight into the role of the general transcription factor, Sp1, in the expression of nuclear genes involved in mitochondrial biogenesis, we investigated Sp1 activation of the adenine nucleotide translocator 2, cytochrome c1, F1-ATPase beta subunit, and the mitochondria transcription factor (mtTFA) promoters transfected into Drosophila cell lines. The numbers and organization of GC elements vary in the four promoters, but the magnitude of activation by coexpressed human Sp1 was similar… CONTINUE READING

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