On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells.

@article{Costa2011OnTR,
  title={On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells.},
  author={Maria Adelina Costa and A Barbosa and Estrela Neto and Ana S{\'a}-e-Sousa and Rolando Freitas and J{\'e}ssica M M Neves and Teresa Magalh{\~a}es-Cardoso and F{\'a}tima Ferreirinha and Paulo Correia-de-S{\'a}},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 5},
  pages={1353-66}
}
Purines are important modulators of bone cell biology. ATP is metabolized into adenosine by human primary osteoblast cells (HPOC); due to very low activity of adenosine deaminase, the nucleoside is the end product of the ecto-nucleotidase cascade. We, therefore, investigated the expression and function of adenosine receptor subtypes (A(1) , A(2A) , A(2B) , and A(3) ) during proliferation and osteogenic differentiation of HPOC. Adenosine A(1) (CPA), A(2A) (CGS21680C), A(2B) (NECA), and A(3) (2… CONTINUE READING
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