On the role of self-recognition in T cell responses to foreign antigen.

@article{tefanov2003OnTR,
  title={On the role of self-recognition in T cell responses to foreign antigen.},
  author={Irena {\vS}tefanov{\'a} and Jeffrey R. Dorfman and Makoto Tsukamoto and Ronald N. Germain},
  journal={Immunological reviews},
  year={2003},
  volume={191},
  pages={97-106}
}
The key role of the thymus in shaping the peripheral T cell receptor (TCR) repertoire has been appreciated for nearly a quarter of a century. For most of that time, a single model has dominated thinking about the physiological role of the positive selection process mediated by TCR recognition of self-peptides and major histocompatibility complex (MHC) molecules. This developmental filter was believed to populate secondary lymphoid tissues with T cells bearing receptors best able to recognize… CONTINUE READING