On the role of prolyl oligopeptidase in health and disease

  title={On the role of prolyl oligopeptidase in health and disease},
  author={J Arturo Garc{\'i}a-Horsman and Pekka T. M{\"a}nnist{\"o} and Jarkko I. Ven{\"a}l{\"a}inen},
Prolyl oligopeptidase (POP) is a serine peptidase which digests small peptide-like hormones, neuroactive peptides, and various cellular factors. Therefore, this peptidase has been implicated in many physiological processes as well as in some psychiatric disorders, most probably through interference in inositol cycle. Intense research has been performed to elucidate, on the one hand, the basic structure, ligand binding, and kinetic properties of POP, and on the other, the pharmacology of its… CONTINUE READING


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