On the role of granule yield strength for the compactibility of granular solids.

  title={On the role of granule yield strength for the compactibility of granular solids.},
  author={Josefina Nordstr{\"o}m and Ken Welch and G{\"o}ran Frenning and G{\"o}ran Alderborn},
  journal={Journal of pharmaceutical sciences},
  volume={97 11},
The objective of this article was to explore the relationship between mechanical properties of single granules and the evolution in tensile strength and tablet micro-structure. Granules of different expected deformation behavior were used as model materials. It is suggested that the role of plasticity in this context is twofold: firstly, to affect the rate of compactibility and thus the pressure range needed to reach the maximal attained tablet strength and, secondly, to affect the mode of… CONTINUE READING


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