On the role of feedback in promoting conflicting goals of the adaptive immune system.

@article{Segel1999OnTR,
  title={On the role of feedback in promoting conflicting goals of the adaptive immune system.},
  author={Lee A. Segel and Ruth Lev Bar-Or},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1342-9}
}
We explored here the implications of two premises. 1) In their response over days or weeks to pathogen invasion, cells of the immune system combine several overlapping and perhaps contradictory goals. 2) The immune system has ways to monitor progress toward these goals via receptors that bind chemicals whose concentrations are related to such progress. We illustrate with simple mathematical models how such monitoring can lead to feedbacks that improve the efficiency of a given effector type in… CONTINUE READING