On the role of dihydrostreptomycin in streptomycin biosynthesis

@article{Maier1975OnTR,
  title={On the role of dihydrostreptomycin in streptomycin biosynthesis},
  author={S. T. Maier and Ulrich Matern and Hans Grisebach},
  journal={FEBS Letters},
  year={1975},
  volume={49}
}
16 Citations
Biosynthesis of Streptomycin
dTDP-l-dihydrostreptose: streptidine-6-phosphate dihydrostreptosyltransferase, an enzyme involved in the biosynthesis of streptomycin, has been purified from Streptomyces griseus to near homogeneity
Biosynthesis of aminocyclitol antibiotics.
TLDR
The history of the aminocyclitol antibiotics dates from the discovery in 1943 of streptomycin by Waksman’s group at Rutgers to the discovery of neomycin, parommycin, kanamycin, gentamicin, sisomicin, butirosin, ribostamycin and hygromycin.
Biosynthesis and Mutasynthesis of Aminoglycoside Antibiotics
The discovery of streptomycin by Waksman in 1944 contributed significantly to the therapy of tuberculosis and initiated the era of aminoglycoside antibiotic research. Following the discovery of
Aminoglycoside Antibiotics
R factor Rmsl51 is an fi+ R factor and belongs to a incompatibility group FIT. It carries the genes governing resistance to various aminoglycoside antibiotics, i.e., kanamycin (KM), lividomycin (LV),
[Secondary metabolites as endogenous effectors of microbial cytodifferentiation].
  • U. Gräfe
  • Biology
    Zeitschrift fur allgemeine Mikrobiologie
  • 1983
TLDR
The present survey covers the regulatory role of microbial secondary metabolites and related compounds as endogenous signals of cell differentiation of the producing organisms and the hormone-like interference of particular metabolites with differentiating cells.
[Possibilities for direct manipulation of gene expression of microbial secondary metabolism].
  • U. Gräfe
  • Biology
    Zeitschrift fur allgemeine Mikrobiologie
  • 1981
TLDR
Some potential ways for the quantitative and the qualitative improvement of secondary metabolite production are discussed, and the scope and limitations of rational strategies of strain improvement by genetic and physiologic manipulations are subjected to final discussion.
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References

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TLDR
Evidence is presented that S. griseus synthesizes myo-inositol from d-glucose and that the organism interconverts myo, inositol and scyllo-Inositol, which support a mechanism involving multiple inversion of the asymmetrical carbon atoms of d- glucose to from the l-sugar.
NADPH-dependent formation of thymidine diphosphodihydrostreptose from thymidine diphospho-D-glucose in a cell-free system from Streptomyces griseus and its correlation with streptomycin biosynthesis.
TLDR
A good correlation between the activity of “dTDP-dihydrostreptose synthase”, arginine : x-amidinotransferase activity and streptomycin production was found in several strains of S. griseus.
Dihydrostreptomycin produced by direct fermentation.
TLDR
The antibiotics screening group found two streptomycetes which produced an antibiotic chromatographically indistinguishable from dihydrostreptomycin, and obtained the organisms, increased their productivity, and identified the antibiotic.
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