On the role of complement and Fc gamma-receptors in the Arthus reaction.

@article{Koehl1999OnTR,
  title={On the role of complement and Fc gamma-receptors in the Arthus reaction.},
  author={Joerg Koehl and J. Engelbert Gessner},
  journal={Molecular immunology},
  year={1999},
  volume={36 13-14},
  pages={893-903}
}
The contribution of either the complement system or the activation of Fc receptors for IgG (FcyRs) to the inflammatory response in immune complex (IC) disease is puzzling. A series of studies has been performed in mice with engineered deficiencies of either FcgammaRs, the complement components C3, C4 or the C5a receptor. In addition, different C5-deficient mice strains have been evaluated. Mice with gene targeted disruption of the gamma-subunit, which mediates surface expression and signal… CONTINUE READING