On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells.

@article{Martin2003OnTR,
  title={On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells.},
  author={Bruno Martin and Christine Bourgeois and Nicole Dautigny and Bruno Lucas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 10},
  pages={6021-6}
}
CD4(+) T cells expand after transfer into lymphopenic H-2(b) A(beta)-/- mice (I-A(beta)-, I-E(alpha)-deficient mice) but not after transfer into lymphopenic MHC II(Delta/Delta) mice (I-A(alpha)-, I-A(beta)-, I-E(alpha)-, and I-E(beta)-deficient mice), implying that in H-2(b) A(beta)-/- mice, A(alpha) chain and E(beta) chain associate to form a hybrid A(alpha)E(beta) MHC class II molecule. In light of this unexpected result, we reexamined the MHC class II requirement in the survival and… CONTINUE READING

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Bone Marrow Transplant

  • C. Tanchot, A. Le Campion, B. Martin, S. Léaument, N. Dautigny, B. Lucas
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