On the road to cancer: aneuploidy and the mitotic checkpoint

@article{Kops2005OnTR,
  title={On the road to cancer: aneuploidy and the mitotic checkpoint},
  author={G. Kops and B. A. Weaver and D. Cleveland},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={773-785}
}
Abnormal chromosome content — also known as aneuploidy — is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis… Expand
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