On the relevance of non-random polypeptide conformations for protein folding.

@article{Creighton1988OnTR,
  title={On the relevance of non-random polypeptide conformations for protein folding.},
  author={Thomas E. Creighton},
  journal={Biophysical chemistry},
  year={1988},
  volume={31 1-2},
  pages={155-62}
}
The possibility that any non-random conformation in reduced bovine pancreatic trypsin inhibitor (BPTI) and ribonuclease A might be significant for folding has been considered, using the experimental data available on forming the first disulphide bond in each. It is a thermodynamic necessity that whatever conformation stabilises a particular disulphide bond be stabilised to the same extent by the presence of the disulphide. The stabilising effects of disulphides are known approximately, so the… CONTINUE READING

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