On the relationship between inflammation and altered cAMP metabolism in lungs ofB. Pertussis-vaccinated mice

Abstract

Bordetella pertussis-vaccinated mice were examined for evidence of inflammation. Using polymorphonuclear leukocyte and fluid accumulation as markers, inflammation was evidenced in the lungs and to a lesser extent in the livers of such mice. Both heart and kidney showed no evidence of inflammation. Development of the inflammatory lesion followed a time course similar to that previously reported for increased sensitivity to histamine-mediated cAMP accumulation. This close parallelism between inflammation and altered cAMP metabolism supports the hypothesis that the increased cAMP accumulation might be related to a feedback mechanism regulating inflammatory mediator release.

DOI: 10.1007/BF00917317

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Cite this paper

@article{Ortez1978OnTR, title={On the relationship between inflammation and altered cAMP metabolism in lungs ofB. Pertussis-vaccinated mice}, author={Richard A. Ortez}, journal={Inflammation}, year={1978}, volume={3}, pages={1-6} }