On the regulation and activation of JAK2: a novel hypothetical model.

@article{Lee2013OnTR,
  title={On the regulation and activation of JAK2: a novel hypothetical model.},
  author={Tai-Sung Lee},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 8},
  pages={
          811-4
        }
}
UNLABELLED Janus kinase 2 (JAK2) is a protein tyrosine kinase central to a multitude of cellular processes. Here, a novel model of JAK2 regulation and activation is proposed. In the JAK2 dimer, instead of being auto-inhibited by its own JH2 domain, inhibition comes from the JH2 domain of the partnering JAK2 monomer. Upon ligand binding, the receptor undergoes a conformational rotation that is passed to its dimeric partner. The activation is achieved by the rotation of two JAK2 molecules, which… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

ELR510444, a novel microtubule disruptor with multiple mechanisms of action.

  • The Journal of pharmacology and experimental therapeutics
  • 2011
VIEW 1 EXCERPT

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