On the reaction mechanism of class Pi glutathione S-transferase.


Theoretical calculations were performed to examine the ionization of the phenolic group of Tyr7 and the thiol group of glutathione in aqueous solution and in the protein class-pi glutathione S-transferase (GST-Pi). Three model systems were considered for simulations in the protein environments the free enzyme, the complex between glutathione and the enzyme… (More)


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@article{Orozco1997OnTR, title={On the reaction mechanism of class Pi glutathione S-transferase.}, author={Modesto Orozco and Carolina Armijo de Vega and Alejandro P{\'a}rraga and Isabel Garc{\'i}a-S{\'a}ez and Miquel Coll and Sinead B. Walsh and Timothy J. Mantle and F Javier Luque}, journal={Proteins}, year={1997}, volume={28 4}, pages={530-42} }