On the rate of molecular evolution

@article{Kimura2005OnTR,
  title={On the rate of molecular evolution},
  author={Motoo Kimura and Tomoko Ohta},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={1},
  pages={1-17}
}
SummaryThere are at least two outstanding features that characterize the rate of evolution at the molecular level as compared with that at the phenotypic level. They are; (1) remarkable uniformity for each molecule, and (2) very high overall rate when extrapolated to the whole DNA content.The population dynamics for the rate of mutant substitution was developed, and it was shown that if mutant substitutions in the population are carried out mainly by natural selection, the rate of substitution… 

The Rate of Molecular Evolution When Mutation May Not Be Weak

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The Rate of Molecular Evolution When Mutation May Not Be Weak

A direct and transparent theoretical analysis of the Wright-Fisher model of population genetics shows that some of the most important rules of molecular evolution are fundamentally changed by considering recurrent mutation's full e↵ect.

The Rate of Observable Molecular Evolution When Mutation May Not Be Weak

A direct and transparent theoretical analysis of the Wright-Fisher model of population genetics shows that some of the most important rules of molecular evolution are fundamentally changed by considering recurrent mutation’s full effect.

Molecular evolutionary clock and the neutral theory

  • M. Kimura
  • Biology
    Journal of Molecular Evolution
  • 2005
It was pointed out that experimental studies should be done to settle the issue of whether the mutation rate for nucleotide change is more constant per year or per generation among organisms whose generation spans are very different.

A generation time effect on the rate of molecular evolution in invertebrates.

Significant evidence is found that rates of molecular evolution are correlated with generation time in invertebrates and that this effect applies consistently across genes and taxonomic groups.

Evolutionary processes and evolutionary noise at the molecular level

It is proposed that evolutionarily significant substitutions may be identified by monitoring changes in functional density and weighted functional density, and it is shown that a certain category of changes in the internal environment of the organism can be integrated into the constantenvironment model for selection.

Solutions to the Cost-of-Selection Dilemma ( substitutional load / gene substitution / evolutionary rate )

In the attempt to study the cost-of-selection dilemma broadly and systematically, it is found necessary to amplify Haldane's original model, and to specify some assumptions which were only implicit in the original papers.

Epistasis Increases the Rate of Conditionally Neutral Substitution in an Adapting Population

Simulated, asexual populations of RNA molecules are studied and it is observed that conditionally neutral mutations—i.e., mutations that do not alter the fitness of the individual in which they arise, but that may alter the Fitness effects of subsequent mutations—substitute much more often than expected while a population is adapting.

Accumulation pattern of amino acid substitutions in protein evolution

It is suggested that the NVS of cytochrome c has been almost constant even over the long period of bacterial evolution but that at least two different substitution rates are necessary to describe the accumulated changes in the sequence.

Weak Selection and Protein Evolution

The motivation for the nearly neutral theory is reviewed, the structure of the model and its predictions are discussed, and current empirical support for interactions among weak evolutionary forces in protein evolution is evaluated.
...

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