On the putative physiological role of allopregnanolone on GABA(A) receptor function.

@article{Puia2003OnTP,
  title={On the putative physiological role of allopregnanolone on GABA(A) receptor function.},
  author={Giulia Puia and J M Mienville and Kojiro Matsumoto and Hiroki Takahata and Hiroshi Watanabe and Erminio Costa and Alessandro Guidotti},
  journal={Neuropharmacology},
  year={2003},
  volume={44 1},
  pages={49-55}
}
To obtain definitive evidence for a physiological allosteric modulatory role for endogenous brain ALLO on GABA(A) receptor function, we studied GABA(A) receptor activity under conditions in which the concentration of endogenous brain ALLO was decreased by about 80% for longer than 5 h following the administration of SKF 105111- 17beta-17-[bis (1methylethyl) amino carbonyl] androstane-3,5-diene-3-carboxylic acid (SKF), a potent inhibitor of 5alpha-reductases Type I and II. We used the in situ… CONTINUE READING
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