On the proper use of the crossover design in clinical trials: part 18 of a series on evaluation of scientific publications.

@article{Wellek2012OnTP,
  title={On the proper use of the crossover design in clinical trials: part 18 of a series on evaluation of scientific publications.},
  author={Stefan Wellek and Maria Blettner},
  journal={Deutsches Arzteblatt international},
  year={2012},
  volume={109 15},
  pages={276-81}
}
BACKGROUND Many clinical trials have a crossover design. Certain considerations that are relevant to the crossover design, but play no role in standard parallel-group trials, must receive adequate attention in trial planning and data analysis for the results to be of scientific value. METHODS The authors present the basic statistical methods required for the analysis of crossover trials, referring to standard statistical texts. RESULTS In the simplest and most common scenario, a crossover… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

Similar Papers

Loading similar papers…