On the process of cellular division in Escherichia coli: replication of the bacterial chromosome under control of prophage P2.

@article{Lindahl1971OnTP,
  title={On the process of cellular division in Escherichia coli: replication of the bacterial chromosome under control of prophage P2.},
  author={Gunnar Lindahl and Yoshiko Hirota and François Jacob},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1971},
  volume={68 10},
  pages={2407-11}
}
The temperature-sensitive mutant CRT46 of Escherichia coli K12 is unable to initiate new rounds of DNA replication at 42 degrees C. Mutants of bacteriophage P2 have been isolated, which, in the prophage state, allow mutant CRT46 to grow at 42 degrees C. The lysogenic bacteria that grow at 42 degrees C are apparently replicating under the control of prophage P2, which substitutes for the bacterial initiation system. The ability of prophage P2 cause this suppression phenomenon depends on the… CONTINUE READING