On the physical basis for ambiguity in genetic coding interactions.

  title={On the physical basis for ambiguity in genetic coding interactions.},
  author={Henri Grosjean and S de Henau and D. M. Crothers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={75 2},
We report the relative stabilities, in the form of complex lifetimes, of complexes between the tRNAs complementary, or nearly so, in their anticodons. The results show striking parallels with the genetic coding rules, including the wobble interaction and the role of modified nucleotides S2U and V (a 5-oxyacetic acid derivative of U). One important difference between the genetic code and the pairing rules in the tRNA-tRNA interaction is the stability in the latter of the short wobble pairs… CONTINUE READING

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