On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans.

  title={On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans.},
  author={Jan O Liliemark and Gunnar Juliusson},
  journal={Cancer research},
  volume={51 20},
The antitumoral effect of 2-chloro-2'-deoxyadenosine (CdA) in the treatment of lymphoproliferative diseases in general and of hairy cell leukemia in particular has recently been demonstrated. Detailed information on the pharmacokinetics of CdA, however, is lacking. The pharmacokinetics of CdA after 2- and 24-h infusions of 0.14 mg/kg was described in 12 patients with lymphoproliferative diseases using a newly developed high-performance liquid chromatography method. The plasma concentration data… CONTINUE READING