On the pathogenesis of mitochondrial myopathies

@article{Sahgal2004OnTP,
  title={On the pathogenesis of mitochondrial myopathies},
  author={Vinod Sahgal and Vellaiyan Subramani and Rosin Hughes and Anu Shah and Himadri Singh},
  journal={Acta Neuropathologica},
  year={2004},
  volume={46},
  pages={177-183}
}
The intra-arterial injection of 2–4 dinitrophenol, an uncoupler of oxidative phosphorylation, resulted in the production of ragged red fibers. The ultrastructure of these fibers showed intramitochondrial paracrystalline inclusions, laminar and fingerprint bodies. Antimycin A and oligomycin injection (which inhibit mitochondrial respiration) only caused swelling and disruption of the mitochondria. An increase in muscle lactic acid, decrease in ATP, glycogen and phosphocreatine was observed after… CONTINUE READING

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