On the pathogenesis of mitochondrial myopathies

  title={On the pathogenesis of mitochondrial myopathies},
  author={Vinod Sahgal and Vellaiyan Subramani and Rosin Hughes and Anu Shah and Himadri Singh},
  journal={Acta Neuropathologica},
The intra-arterial injection of 2–4 dinitrophenol, an uncoupler of oxidative phosphorylation, resulted in the production of ragged red fibers. The ultrastructure of these fibers showed intramitochondrial paracrystalline inclusions, laminar and fingerprint bodies. Antimycin A and oligomycin injection (which inhibit mitochondrial respiration) only caused swelling and disruption of the mitochondria. An increase in muscle lactic acid, decrease in ATP, glycogen and phosphocreatine was observed after… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 21 references

A mitochondrial myopathy characterized by deficiency of reducible cytochrome B

  • J. A. Morgan-Hughes, P. Darveniza, +4 authors J. B. Clark
  • Brain
  • 1977

Oxidative phosphorylase in progressive muscular dystrophy

  • K. Wrogemann, B. E. Jacobsen, M. C. Blaniler
  • Clinical studies in myology, Part II. New York…
  • 1973
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