On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra

@article{Brownstein1977OnTO,
  title={On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra},
  author={Michael J. Brownstein and Edmund A. Mroz and Marcel L. Tappaz and Susan E Leeman},
  journal={Brain Research},
  year={1977},
  volume={135},
  pages={315-323}
}
Knife cuts in the frontal plane separating the anterior part of the caudate-putamen from the globus pallidus resulted in marked decreases in substances P levels in the reticular part of the substantia nigra. More caudal knife cuts were required in order to effect maximal decreases in nigral glutamic acid decarboxylase levels. Thus, there is a clear anatomical dissociation between the striatal neurons which project to the reticular part of the substantia nigra and which contain SP, and the more… CONTINUE READING

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