On the origin of leprosy

@article{Cole2005OnTO,
  title={On the origin of leprosy},
  author={Stewart Thomas Cole and Marc Monot and Nadine Honoré},
  journal={BMC Proceedings},
  year={2005},
  volume={2},
  pages={1}
}
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease… 

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Comparative genomics of four different strains from India, Brazil, Thailand, and the USA revealed remarkable conservation of the ~3.27-megabase genome yet uncovered 215 polymorphic sites, mainly single-nucleotide polymorphisms (SNP), and a handful of new pseudogenes that helped retrace the evolution of M. leprae and the dissemination of leprosy.

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Comparative genomics of four different strains revealed remarkable conservation of the genome yet uncovered 215 polymorphic sites, mainly single nucleotide polymorphisms, and a handful of new pseudogenes, which helped retrace the evolution of M. leprae.

[Leprosy in a chimpanzee].

  • N. IshiiT. Udono Koichi Suzuki
  • Biology, Medicine
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
  • 2011
A rare case of leprosy is found in a chimpanzee born in West Africa and brought to Japan around 2 years of age, and single-nucleotide polymorphism (SNP) analysis verified the West African origin of the bacilli.

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These studies indicate that a favorable host genetic make-up, combined with environmental and pathogen-related variables, has a high impact on the definition of susceptibility to both infection and clinical manifestation of leprosy.
...

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