On the origin of POU5F1

  title={On the origin of POU5F1},
  author={Stephen R. Frankenberg and Marilyn B Renfree},
  booktitle={BMC Biology},
Pluripotency is a fundamental property of early mammalian development but it is currently unclear to what extent its cellular mechanisms are conserved in vertebrates or metazoans. POU5F1 and POU2 are the two principle members constituting the class V POU domain family of transcription factors, thought to have a conserved role in the regulation of pluripotency in vertebrates as well as germ cell maintenance and neural patterning. They have undergone a complex pattern of evolution which is poorly… CONTINUE READING
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