On the optimization of drug release from multi-laminated polymer matrix devices.

@article{Georgiadis2001OnTO,
  title={On the optimization of drug release from multi-laminated polymer matrix devices.},
  author={Michael C. Georgiadis and Margaritis Kostoglou},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={77 3},
  pages={
          273-85
        }
}
This work presents a systematic optimization framework to achieve desired release rates in drug delivery devices using multi-laminated layers. A simple mathematical model is used to describe the transient mass transfer between successive layers, laminated together to form matrices with different initial concentrations, drug diffusivities and thickness. First, an efficient analytical-based optimization approach is investigated to define the optimal nonuniform initial drug distribution for… CONTINUE READING

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