On the nature of the mitochondrial proton leak.

  title={On the nature of the mitochondrial proton leak.},
  author={Guy C Brown and Martin D. Brand},
  journal={Biochimica et biophysica acta},
  volume={1059 1},
Respiring mitochondria have a significant passive permeability to protons; the mechanism of this proton leak is unknown. Several putative mechanisms were tested. Mitochondrial permeability to small sugars was unaffected by energization, suggesting that there is no significant dielectric breakdown at high membrane potential. Mitochondria are argued to have a… CONTINUE READING