On the nature of the BOLD fMRI contrast mechanism.

  title={On the nature of the BOLD fMRI contrast mechanism.},
  author={Nikos K. Logothetis and Josef Pfeuffer},
  journal={Magnetic resonance imaging},
  volume={22 10},
Since its development about 15 years ago, functional magnetic resonance imaging (fMRI) has become the leading research tool for mapping brain activity. The technique works by detecting the levels of oxygen in the blood, point by point, throughout the brain. In other words, it relies on a surrogate signal, resulting from changes in oxygenation, blood volume and flow, and does not directly measure neural activity. Although a relationship between changes in brain activity and blood flow has long… CONTINUE READING

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