On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain.

@article{Bennett1995OnTM,
  title={On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain.},
  author={Paul B. Bennett and Carmen Valenzuela and Li Qian Chen and Roland G. Kallen},
  journal={Circulation research},
  year={1995},
  volume={77 3},
  pages={584-92}
}
The mechanism of inhibition of Na+ channels by lidocaine has been suggested to involve low-affinity binding to rested states and high-affinity binding to the inactivated state of the channel, implying either multiple receptor sites or allosteric modulation of receptor affinity. Alternatively, the lidocaine receptor may be guarded by the channel gates. To… CONTINUE READING