On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport.

@article{Montigny2016OnTM,
  title={On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport.},
  author={C{\'e}dric Montigny and Joseph A Lyons and Philippe Champeil and Poul Nissen and Guillaume Lenoir},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1861 8 Pt B},
  pages={
          767-783
        }
}
Phospholipid flippases are key regulators of transbilayer lipid asymmetry in eukaryotic cell membranes, critical to many trafficking and signaling pathways. P4-ATPases, in particular, are responsible for the uphill transport of phospholipids from the exoplasmic to the cytosolic leaflet of the plasma membrane, as well as membranes of the late secretory/endocytic pathways, thereby establishing transbilayer asymmetry. Recent studies combining cell biology and biochemical approaches have improved… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Decoding P4-ATPase substrate interactions.

  • Critical reviews in biochemistry and molecular biology
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Diverse relations between ABC transporters and lipids: An overview.

  • Biochimica et biophysica acta. Biomembranes
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 185 REFERENCES

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Reconstitution of ATP-dependent aminophospholipid translocation in proteoliposomes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
VIEW 18 EXCERPTS
HIGHLY INFLUENTIAL

The interaction of vanadate ions with the Ca-ATPase from sarcoplasmic reticulum.

  • The Journal of biological chemistry
  • 1982
VIEW 20 EXCERPTS
HIGHLY INFLUENTIAL