Corpus ID: 29386365

On the mode of action of levallorphan on Escherichia coli: effects on cellular magnesium.

@article{Devynck1971OnTM,
  title={On the mode of action of levallorphan on Escherichia coli: effects on cellular magnesium.},
  author={M. Devynck and P. Boquet and P. Fromageot},
  journal={Molecular pharmacology},
  year={1971},
  volume={7 6},
  pages={
          605-10
        }
}
Inhibition of the growth of Escherichia coli by levallorphan increased in effectiveness as the medium concentration of Mg++ was decreased. Two molecules of levallorphan were shown to compete with 1 atom of Mg++, presumably on the cell surface. Active transport of Mg++ was altered in the presence of the drug, and this effect could be prevented by high concentrations of Ca++. Reduction of cellular Mg++ content in the presence of levallorphan is suggested to be one possible cause of growth… Expand

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