On the mode of action of emodepside: slow effects on membrane potential and voltage-activated currents in Ascaris suum.

@article{Buxton2011OnTM,
  title={On the mode of action of emodepside: slow effects on membrane potential and voltage-activated currents in Ascaris suum.},
  author={Samuel K. Buxton and Cedric Neveu and Claude L. Charvet and Alan P Robertson and Richard J. Martin},
  journal={British journal of pharmacology},
  year={2011},
  volume={164 2b},
  pages={
          453-70
        }
}
BACKGROUND AND PURPOSE Anthelmintics are required for treatment and prophylaxis of nematode parasites of humans and domestic animals. Emodepside, a cyclooctadepsipeptide, is a modern anthelmintic that has a novel mode of action involving a Ca-activated K channel (SLO-1) in Caenorhabditis elegans, sometimes mediated by a latrophilin (LAT) receptor. We examined mechanisms of action of emodepside in a parasitic nematode, Ascaris suum. EXPERIMENTAL APPROACH RT-PCR was used to investigate… CONTINUE READING