On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coli

@inproceedings{Berg2016OnTM,
  title={On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coli},
  author={J Jasper van den Berg and Heloisa Galbiati and Akiko Rasmussen and Samantha K Miller and Bert Poolman},
  booktitle={Scientific reports},
  year={2016}
}
Bacterial mechanosensitive channels protect cells from structural damage during hypoosmotic shock. MscS, MscL and MscK are the most abundant channels in E. coli and arguably the most important ones in osmoprotection. By combining physiological assays with quantitative photo-activated localization microscopy (qPALM), we find an almost linear relationship between channel abundance and cell survival. A minimum of 100 MscL (or MscS) channels is needed for protection when a single type of channel is… CONTINUE READING
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