On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

@article{Papini1988OnTM,
  title={On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.},
  author={Emanuele Papini and Doriana Sandon{\`a} and Rino Rappuoli and Cesare Montecucco},
  journal={The EMBO journal},
  year={1988},
  volume={7 11},
  pages={3353-9}
}
Diphtheria toxin (DT) in acidic media forms ion-conducting channels across the plasma membrane and inhibits protein synthesis of both highly and poorly DT-sensitive cell lines. This results in loss of cell potassium and in entry of both sodium and protons with a concomitant rapid lowering of membrane potential. The pH dependency of the permeability changes is similar to that of the inhibition of cell protein synthesis. DT-induced ion channels close when the pH of the external medium is returned… CONTINUE READING