On the mechanisms of neuroprotection by creatine and phosphocreatine.

  title={On the mechanisms of neuroprotection by creatine and phosphocreatine.},
  author={Nickolay Brustovetsky and Tatiana Brustovetsky and Janet M. Dubinsky},
  journal={Journal of neurochemistry},
  volume={76 2},
Creatine and phosphocreatine were evaluated for their ability to prevent death of cultured striatal and hippocampal neurons exposed to either glutamate or 3-nitropropionic acid (3NP) and to inhibit the mitochondrial permeability transition in CNS mitochondria. Phosphocreatine (PCr), and to a lesser extent creatine (Cr), but not (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK801), dose-dependently ameliorated 3NP toxicity when applied simultaneously… CONTINUE READING


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