On the mechanisms involved in antinociception induced by diphenyl diselenide.

@article{Zasso2005OnTM,
  title={On the mechanisms involved in antinociception induced by diphenyl diselenide.},
  author={Fabricio Batistella Zasso and Carlos E P Goncales and Eduardo Affonso Jung and Dion{\'e}ia Araldi and Gilson Rog{\'e}rio Zeni and Jo{\~a}o Batista T Rocha and Cristina Wayne Nogueira},
  journal={Environmental toxicology and pharmacology},
  year={2005},
  volume={19 2},
  pages={
          283-9
        }
}
In this study, we described the local peripheral antinociceptive activity produced by diphenyl diselenide in the formalin test as compared to ebselen, an amply studied organoselenium compound. A second objective was to evaluate, the possible mechanisms underlying the antinociceptive effect caused by diphenyl diselenide. Administration of diphenyl diselenide or ebselen produced a significant antinociceptive local effect on the late phase (15-30min) of the formalin test. As well, diphenyl… Expand
Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test
This study investigated the mechanisms involved in the antinociceptive action induced by diphenyl diselenide ((PhSe)2) in the formalin test. Mice were pre‐treated with (PhSe)2 by the oral routeExpand
Spinal mechanisms of antinociceptive action caused by diphenyl diselenide
TLDR
Results indicate that diphenyl diselenide produced antinociception at spinal sites, with a possible interaction with glutamatergic pathways, more specifically via interaction with NMDA receptors, peptidergic or vanilloid systems. Expand
Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats
TLDR
It is demonstrated that the antidepressant-like effect caused by diphenyl diselenide seems to be mediated by involvement of the central monoaminergic system. Expand
Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action.
TLDR
Results indicate that diphenyl diselenide produced antinociception in several models of pain through mechanisms that involve an interaction with not only nitrergic system but also via interaction with redox modulatory sites of glutamate receptors. Expand
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice
TLDR
The results indicate that (MeOPhSe)(2) produces antinociceptive effect in several models of nociception through mechanisms that involve an interaction with glutamatergic and GABAergic systems, as well as the inhibition of protein kinase A pathway. Expand
Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice
TLDR
(MeOPhSe)(2) produced antinociception in mice through mechanisms that involve an interaction with nitrergic system, 5-HT(3) and D(1) receptors and PKC pathway mediated mechanisms. Expand
Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: Putative roles of GABAA and 5HT receptors
TLDR
All the antagonists used were able to abolish the anxiolytic effect of (PhSe)2 suggesting that GABAA and 5HT receptors may play a role in the pharmacological property of this selenocompound in the central nervous system. Expand
Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats.
TLDR
It is indicated that (PhSe)2 had a potential antinociceptive and anti-inflammatory action in the MSG model and was effective in reversing all alterations caused by MSG. Expand
Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems.
TLDR
The results indicate that butyl (2-phenylethynyl) selenide produced antinociception in the formalin test through mechanisms that involve an interaction with serotonergic (5-HT(3)) and adenosinergic systems. Expand
Caffeine and a selective adenosine A2B receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice
TLDR
The results indicate that diphenyl diselenide produced antinociception in a thermal model of pain in mice and its effect was prevented by caffeine and by a selective adenosine A(2B) receptor, but not by imidazoline receptor antagonists in mice. Expand
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