On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients.

@article{Redelmeier1990OnTM,
  title={On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients.},
  author={Thomas Redelmeier and Michael J. Hope and Pieter R Cullis},
  journal={Biochemistry},
  year={1990},
  volume={29 12},
  pages={3046-53}
}
Previous work [Hope et al. (1989) Biochemistry 28, 4181-4187] has shown that asymmetric transmembrane distributions of phosphatidylglycerol (PG) in PG-phosphatidylcholine (PC) large unilamellar vesicles can be induced in response to transbilayer pH gradients (delta pH). Here the mechanism of PG transport has been investigated. It is shown that PG movement in response to delta pH is consistent with permeation of the uncharged (protonated) form and that the half-time for transbilayer movement of… CONTINUE READING

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