On the mechanism of tolerance to the Rh D antigen mediated by passive anti-D (Rh D prophylaxis).

@article{Kumpel2002OnTM,
  title={On the mechanism of tolerance to the Rh D antigen mediated by passive anti-D (Rh D prophylaxis).},
  author={Belinda M Kumpel},
  journal={Immunology letters},
  year={2002},
  volume={82 1-2},
  pages={67-73}
}
Anti-D prophylaxis is the most successful clinical application of antibody-mediated immune suppression. Passive IgG anti-D is given to Rh D-negative women to prevent immunisation to foetal Rh D-positive red blood cells (RBC) and subsequent haemolytic disease of the newborn. Despite its widespread use and efficacy, the mechanism of action of this therapy is unproven. The known facts about the antigen, antibody response, dose of anti-D, RBC clearance and effects of the passive anti-D on… CONTINUE READING

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