On the mechanism of thrombin-induced angiogenesis : Involvement of ανβ 3 integrin

Abstract

Thrombin was reported to be a potent angiogenic factor both in vitro and in vivo and many of the cellular effects of thrombin may contribute to activation of angiogenesis. In this report we show that thrombin-treatment of human endothelial cells increases mRNA and protein levels of ανβ3 integrin. This thrombin-mediated effect is specific, dose-dependent and… (More)

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