On the mechanism of release of norepinephrine from cat spleen slices by sodium deprivation and calcium pretreatment.


Endogenous norepinephrine (NE) content of cat spleen slices was markedly depleted by incubating them in a sodium-free solution for 2 hours at 37 degrees C. Dopamine beta-hydroxylase (DBH) activity was not changed by this treatment. During incubation of the slices in sodium-free solution for 30 minutes at 37 degrees C, there was a marked release of NE into… (More)


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