On the mechanism of protein binding of N-2-fluorenylacetamide. The deacetylation of N-(1-hydroxy-2-fluorenyl)-acetamide and the effect of ethionine.

Abstract

Homogenates of six rat tissues metabolized the o-amidofluorenol, N-(1-hydroxy-~fluorenyl)aeetamide, as judged by the disappearanee of the phenolic hydroxyl group of the compound from the ineubation systems. By the same criterion, N-(7-hydroxy-~fluorenyl)aeetamide was resistant to metabolie attack. The deaeylation of N-(1-hydroxy-~-fluorenyl)aeetamide, N-(7… (More)

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