On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria.

@article{Belosludtsev2006OnTM,
  title={On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria.},
  author={Konstantin N. Belosludtsev and Nils-Erik Leo Saris and Leif C Andersson and Natalia V. Belosludtseva and Alexey V. Agafonov and Ankit R Sharma and Dmitry A. Moshkov and Galina D. Mironova},
  journal={Journal of bioenergetics and biomembranes},
  year={2006},
  volume={38 2},
  pages={113-20}
}
Palmitic acid (Pal) is known to promote apoptosis (Sparagna G et al (2000) Am J Physiol Heart Circ Physiol 279: H2124-H2132) and its amount in blood and mitochondria increases under some pathological conditions. Yet, the mechanism of the proapoptotic action of Pal has not been elucidated. We present evidence for the involvement of the mitochondrial cyclosporin A-insensitive pore induced by Pal/Ca(2+) complexes in the apoptotic process. Opening of this pore led to a fall of the mitochondrial… CONTINUE READING
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