On the mechanism of impairment of renal concentrating ability in hypercalcemia.

  title={On the mechanism of impairment of renal concentrating ability in hypercalcemia.},
  author={Andrzej Manitius and Howard Levitin and Dani Beck and Franklin H. Epstein},
  journal={The Journal of clinical investigation},
A decrease in the ability of the kidneys to concentrate the urine is characteristic of many varieties of experimental and clinical hypercalcemia, hypercalciuria and nephrocalcinosis (1). Vitamin D intoxication in rats (2) and large doses of parathyroid extract in dogs (3, 4), in addition to producing hyposthenuria, have been shown to cause morphological changes which are most marked in the epithelial cells lining the collecting ducts but are also present in the distal convoluted tubules and the… CONTINUE READING


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