On the mechanism of drug release from oil suspensions in vitro using local anesthetics as model drug compounds.


The objective of this study was to gain insight into factors influencing the drug release kinetics from oil suspensions. The in vitro drug release from suspensions was investigated at pH 7.4 using the local anesthetics, bupivacaine and ropivacaine, as model drug compounds. Two dialysis membrane-based in vitro release models differing with respect to… (More)
DOI: 10.1016/j.ejps.2008.02.005


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