On the mechanism of action of the antifungal agent propionate.

@article{Brock2004OnTM,
  title={On the mechanism of action of the antifungal agent propionate.},
  author={Matthias Brock and Wolfgang Buckel},
  journal={European journal of biochemistry},
  year={2004},
  volume={271 15},
  pages={
          3227-41
        }
}
Propionate is used to protect bread and animal feed from moulds. The mode of action of this short-chain fatty acid was studied using Aspergillus nidulans as a model organism. The filamentous fungus is able to grow slowly on propionate, which is oxidized to acetyl-CoA via propionyl-CoA, methylcitrate and pyruvate. Propionate inhibits growth of A. nidulans on glucose but not on acetate; the latter was shown to inhibit propionate oxidation. When grown on glucose a methylcitrate synthase deletion… CONTINUE READING
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