On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

Abstract

Membrane assembly of complement proteins C5b-9 on human platelets results in a dose-dependent increase in the binding of coagulation factors Va and Xa to the plasma membrane, concomitant with a marked increase in platelet prothrombinase activity. Factor Va binding increased by 6-15-fold in platelets treated with the C5b-9 proteins as compared to controls… (More)

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Cite this paper

@article{Wiedmer1986OnTM, title={On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.}, author={Therese Wiedmer and Charles T. Esmon and Peter J. Sims}, journal={The Journal of biological chemistry}, year={1986}, volume={261 31}, pages={14587-92} }