On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.

@article{Rose2004OnTM,
  title={On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2.},
  author={Jeremy J Rose and John F. Foley and Philip G. M. Murphy and S. K. Venkatesan},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 23},
  pages={24372-86}
}
It is well established that leukocyte chemotactic receptors, a subset of G protein-coupled receptors, undergo endocytosis after stimulation by ligand. However, the significance of this phenomenon to cell motility and other important leukocyte functions induced by chemoattractants has not been clearly defined. Here we show that in primary human neutrophils, the threshold levels of agonist required for endocytosis of the chemotactic receptors CXCR1 and CXCR2 were approximately 10-fold or higher… CONTINUE READING