On the location and nature of the action of insulin

  title={On the location and nature of the action of insulin},
  author={Joshua Harold Burn and Henry Hallett Dale},
  journal={The Journal of Physiology},
  • J. Burn, H. Dale
  • Published 9 October 1924
  • Biology, Medicine
  • The Journal of Physiology
THE phenomenon of the disappearance of dextrose from the blood under the influence of injected insulin is now familiar, but the method of the disappearance remains obscure. A full review of the relevant literature has recently been published by Lesser (1924). Suggestions have been made of a change of the dextrose into a reactive form (Winter and Smith)', in which it becomes liable to metabolic attack; but whatever the future may decide as to the validity of this conception, it leaves certain… 
The Fate of the Sugar Disappearing under the Action of Insulin
The apparent disappearance of sugar injected into normal animals has for a long time puzzled physiological investigators and attempts were made to trace the fate of the sugar which disappears from the blood of the normal animal under the influence of an injection of insulin, difficulties were encountered.
The mechanism of action of insulin
  • H. Weil-Malherbe
  • Psychology, Medicine
    Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie
  • 1955
At the present time when the chemical exploration of the insulin molecule has yielded spectacular results (257–259) the physiology of its action is still a matter of speculation. Yet in this field,
Oxidation and Storage of Glucose under the Action of Insulin
The experiments here described represent an attempt to make a complete experimental balance sheet, representing the fate of the whole of the glucose, by simultaneous measurement of the consumption of oxygen and the accumulation of glycogen in the same preparation.
Effects of insulin and muscular exercise upon the uptake of hexoses by muscle cells.
The view that insulin and activation of muscle exert selective effects on the uptake of various hexoses by muscle cells is supported and it appears that it is still impossible to decide whether sugars can cross the cell boundaries in the free state or only by way of some chemical transformation.
The Action of Glucosone on Normal Animals (Mice) and Its Possible Significance in Metabolism
Experimental evidence is furnished against the theory of Winter and Smith that glucose monoacetone, a readily hydrolysable derivative of γ-glucose, is without action when administered in cases of insulin hypoglycaemia.
Insulin and Muscle
Insulin and the heart.
  • M. Krahl
  • Medicine
    Annals of the New York Academy of Sciences
  • 1951
The purpose of this paper is to summarize the present state of knowledge about the means by which insulin enhances glucose uptake by tissues and the nature and loci of action of the anterior pituitary fractions which influence glucose uptake and utilization.
Insulin, Nobel laureates and The Journal of Physiology
The publication of the 600th volume of The Journal of Physiology coincides with the 100th anniversary of the discovery of insulin and offers the Editors an opportunity to highlight The Journal’s


Die Innere Sekretion des Pankreas. Fischer (Jena), 1924. Locke and Rosenheim
  • This. Jourm
  • 1907
Ether. Tracheotomy; carotid arteries tied; decapitated and given artificial respiration
    Ibid. p. 35. 1922. Bissinger, Lesser and Zipf
    • Berl. klin. Wochenschr
    • 1923
    Cat, 2 kgm. Pancreatectomy under ether anasthesia with full aseptic precautions. Mar. 21st. Cat well. 2-5 p.c. sugar in urine
    • Mar
    Hepburn and Latchford Ibid. 62, p. 177. 1922. Kellaway and Hughes
    • Proc. Phys. Soc. xlvii. 1923. Eadie
    • 1923
    , Trevan and Boock . This Journ . 57 , Proc . Phys . Soc . xlvii . 1923 . Eadie , Macleod and Noble
      Bissinger, Lesser and Zipf
      • Ser. m,
      • 1922
      Infusion of 2 p.c. dextrose into 1. ext. jug. vein
        Macleod and Pearce
        • Olmsted and Logan. Amer. J. Physiol
        • 1911
        Ringer (M.)
        • Brit. Med. Journ
        • 1921