On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons.

@article{Howe1988OnTK,
  title={On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons.},
  author={James R. Howe and David Colquhoun and Stuart G Cull-Candy},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1988},
  volume={233 1273},
  pages={407-22}
}
Ion channels activated by glutamate, aspartate, and N-methyl-D-aspartate (NMDA) have been investigated in outside-out patches from cultured cerebellar granule neurons of the rat. Openings of these channels occur in bursts, within which the individual openings are separated by brief shuttings or gaps. The shut-time distributions obtained with each agonist were fitted with four exponential components. The briefest two components were considered as 'gaps within bursts'. Their mean time-constants… CONTINUE READING

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